甘肃11选5

速递 | 阿巴西普治疗免疫检查点抑制剂引起的严重心肌炎

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近日,新英格兰医学期刊刊登了关于阿巴西普一篇最新资讯。主要内容摘录如下:


MIANYIJIANCHADIANYIZHIJI(Immune checkpoint inhibitors,RUPD-1HEPD-L1)BEIGUANGFANYINGYONGYUAIZHENGDEZHILIAO,DANTONGSHIGAILEIYAOWUKENENGHUIYINQIMIANYIXIANGGUANBULIANGFANYING,PIRUYINFAXINJIYANZHENG。TONGSHIBANSUIJIYANHEZHONGZHENGJIWULIDEZHENGZHUANG。JINGUANZHEIZHONGBINGZHENGDEFABINGLVJIAODI(<1%ZHILIAODUIXIANG),DANYIDANFASHENG,DUIYUDUODABANSHUDEHUANZHEJIANGSHIZHIMINGDE。


甘肃11选5WENZHANGTIGONGLEYIGESHIYONGABAXIPU(Abatacept)(CTLA-4Ig)JIEJUESHANGSHUZHENGZHUANGDEANLI。YIWEI66SUIFEIAIZHUANYIDEFUNVZAIJIESHOUSANCINAWUDANKANG(Nivolumab)HOUCHUXIANLESHANGJIANXIACHUI,FUSHIYIJIJINDUANJIROUDEJIXINGTENGTONG,SUIHOUCHUXIANXIONGTONGHEXINDIANTUYICHANG,ZUIZHONGTONGGUOXINZANGDECIGONGZHENYINGXIANGQUEZHENWEIXINJIYAN,JIGAIDANBAITHENANJIMODUANBXINGLINATAIYUANSHUIPINGSHENGGAO。


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JINGUANZAIRUYUANSHIJIYUGAOJILIANGDEJIAJIQIANGDESONGLONGJINGMAIZHUSHE,BINGRENJIGAIDANBAITDESHUIPINGYIRANSHENGGAO,TONGSHIBANSUIZHESHIXINGZAOBO。CONGRUYUANHOUDEDI17TIANKAISHIJINGMAIZHUSHEABAXIPU,JIGAIDANBAISHUIPINGXUNSUXIAJIANG,BINGQIEXINSHIGUODUXINGFENZAI3ZHOUNEIDEYIXIAOTUI,XINJIYAN(XINLVSHICHANG)HEJIYAN(JIWULIHEMIANTAN)DEZHENGZHUANGZHUBUJIANSHAO。BINGRENZAIRUYUAN7.5ZHOUHOUCHUYUAN。ZAIDIYICIABAXIPUZHUSHEYIGEYUEHOUJINXINGHENGDUANCENGMIANYINGXIANGJIANCHA,JIEGUOWEIJIANZHONGLIUJINYIBUFAZHAN。


ZAIZHEILIBINGRENSHANG,CTLA-4Ig(ABAXIPU,CTLA-4MIANYIQIUDANBAIRONGHEDANBAI,YIBEIPIZHUNYONGYUFENGSHIXINGJIBINGHUANZHEDEZHILIAO)XIANSHICHUDUIMIANYIJIANCHADIANYIZHIJIYOUDAODEXINJIYANDEHUANJIEZUOYONG。JIXIANGLINCHUANGQIANYANJIUYEBIAOMINGABAXIPUZHILIAOXINJIYANDEQIANZAILIAOXIAO,BAOHANFENGSHIXINGGUANJIEYANBINGRENDELINCHUANGSHIYANHEXINJIYANBINGRENDEYALINCHUANGSHIYANZHENGZAIKAIZHAN。


CTLA-4Ig(ABAXIPUDENG)KEYIYIZHIJIYUSHUTUXIBAODECD28-B7DUITXIBAODECIJI,YIZHITXIBAOSHANGYOUDECTLA-4HEPD-1,PD-L1XINHAOTONGLU。YINCI,ABAXIPUKEYIKUAISUYIZHIQUANSHENTXIBAODEHUOXING(YIZHIZHENGCHANGDEMIANYIXIANGYING)。


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“阿巴西普是一种选择性的T细胞共刺激因子抑制剂,是细胞毒性T淋巴细胞抗原4与免疫球蛋白IgG1的融合蛋白(CTLA4-Ig)。它可通过与抗原递呈细胞上的CD80/86分子结合来抑制T细胞的活化以及由此产生的炎症级联反应,进而抑制T淋巴细胞相关的B细胞功能,与其他免疫抑制剂作用机理完全不同。


WEILAIBUJINZAILEIFENGSHIZHILIAOZHONGYOUGUANGFANDEYINGYONGQIANJING,SUIZHEGENGDUODELINCHUANGSHIYANKAIZHAN,ZAIZHONGLIUMIANYIJIANCHADIANYIZHIJIZHILIAOZHONGYEKENENGHUIYOUYIXIZHIDI。XINYINGGELANYIXUEZAZHIDEZHEIPIANWENZHANGWEIABAXIPUDUTEDEZUOYONGJILIHELINCHUANGYINGYONGTIGONGLEWEILAIDESIKAOFANGXIANG。”




甘肃11选5YUANWENLIANJIE:https://www.nejm.org/doi/full/10.1056/NEJMc1901677



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